| 引用本文: | 张新国,曾艳龙,陈文洁,李坤.RNAi在肿瘤基因治疗药物研究中的应用[J].中国现代应用药学,2011,28(9):809-816. |
| ZHANG Xinguo,ZENG Yanlong,CHEN Wenjie,LI Kun.Study for RNAi in Tumor Gene Therapy Drugs[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(9):809-816. |
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| 摘要: |
| 肿瘤是多种基因突变的累积以及这些基因相互作用形成的基因网络调控的结果，目前RNA干扰技术越来越多地拓宽到肿瘤医学的研究领域。本文就RNA干扰技术在肿瘤基因治疗、在候选基因的发现和筛选中的应用以及临床研究进展方面做一综述。 |
| 关键词: RNA干扰 肿瘤 基因治疗 癌症 |
| DOI： |
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| 基金项目:兰州理工大学科研发展基金资助项目(0908ZXC126) |
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| Study for RNAi in Tumor Gene Therapy Drugs |
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ZHANG Xinguo, ZENG Yanlong, CHEN Wenjie, LI Kun
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School of Life Science and Technology, Lanzhou University of Technology, Lanzhou 730050, China
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| Abstract: |
| The occurrence of tumor is the results of accumulation of multiple gene mutations, as well as network of gene controlling and regulation arising from the interaction of these genes. At present, more and more RNA interference(RNAi) technology was broadened to the field of tumor medicine. The review is focused on the application of RNAi technology in tumor gene therapy and the discovery and filter of its candidate gene as well as current clinical trials of RNAi-based drugs. |
| Key words: RNAi tumor gene therapy cancer |
