| 引用本文: | 朱培曦，徐慧，王峰，李会林.加合钠离子的血管紧张素转换酶抑制剂类化合物的质谱分析[J].中国现代应用药学,2011,28(10):949-952. |
| ZHU Peixi, XU Hui, WANG Feng, LI Huilin.Analysis of Angiotensin-converting Enzyme Inhibitors by Mass Spectrometry[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(10):949-952. |
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| 摘要: |
| 目的 建立在加合钠离子条件下血管紧张素转换酶抑制剂类化合物质谱鉴定和分析的新方法。方法 电喷雾离子阱质谱，注射泵直接进样。结果 在加合钠离子的条件下，都出现了特殊的重排离子，通过对碎裂离子的分析，总结了这类化合物在加合钠离子的条件下的质谱碎裂特征。结论 采用解析加合钠离子的准分子离子碎裂途径的方法，有助于对这类化合物的结构推断。 |
| 关键词: 电喷雾 离子阱质谱 血管紧张素抑制剂 裂解 |
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| Analysis of Angiotensin-converting Enzyme Inhibitors by Mass Spectrometry |
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ZHU Peixi, XU Hui, WANG Feng, LI Huilin1,2
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1.Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China;2.Taizhou Institute for Marine Environment Monitor Forecast, Taizhou 318000, China
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| Abstract: |
| OBJECTIVE To establish a method for the identification of angiotensin-converting enzyme (ACE) inhibitors. METHODS Electrospray ionization tandem mass spectrometry (ESI-MS2) was employed and samples were introduced by a syringe pump. RESULTS Their fragmentation pathways were described and a unique rearrangement was observed for the eight compounds. CONCLUSION These characters can be used for future studies of ACE inhibitors. |
| Key words: electrospray ionization ion trap mass spectrometry angiotensin-converting enzyme inhibitors dissociation |
