| 引用本文: | 朱海彦,方增军,孙杰,张曼红.热熔制粒在口服固体制剂中的应用[J].中国现代应用药学,2011,28(7):622-629. |
| ZHU Haiyan,FANG Zengjun,SUN Jie,ZHANG Manhong.Application of Hot Melt Granulation in Oral Solid Dosage Forms[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(7):622-629. |
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| 摘要: |
| 目前，多种不同的热熔制粒方法在颗粒剂、片剂、胶囊剂等口服固体制剂的制备中得以应用。本文综述了热熔制粒法的特点、设备、黏合剂、应用、发展趋势、产业化的关键问题及解决途径，重点介绍了具有不同溶解性、起关键作用的低熔点黏合剂。 |
| 关键词: 热熔制粒 低熔点黏合剂 速释固体分散体 水分散粒剂 缓控释制剂 |
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| Application of Hot Melt Granulation in Oral Solid Dosage Forms |
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ZHU Haiyan1, FANG Zengjun2, SUN Jie1, ZHANG Manhong1
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1.Shandong Institute of Pharmaceutical Industry, Shandong Provincial Key Laboratory of Chemical Medicine, Jinan 250101, China;2.The Second Hospital of Shandong University, Jinan 250033, China
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| Abstract: |
| In recent times, various methods of hot melt granulation have been adopted in the preparation of oral solid dosage forms, such as granules, tablets and capsules. This paper presents a review of these methods’ features, equipments, binders, applications, tendencies, problems and solutions of industrial production. Special emphasis is put on binders with low melt point and different solubility, which play crucial roles in hot melt granulation. |
| Key words: hot melt granulation binders with low melt point rapid release solid dispersions water dispersible granules sustained and controlled release dosage forms |
