细胞毒药物与肿瘤血管生成

屠哲玮; 陶一飞; 董缙; 徐云根<sup>*</sup>

引用本文:	屠哲玮,陶一飞,董缙,徐云根.细胞毒药物与肿瘤血管生成[J].中国现代应用药学,2011,28(7):618-622.
	TU Zhewei,TAO Yifei,DONG Jin,XU Yungen.Cytotoxic Drugs and Its Anti-angiogenesis[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(7):618-622.

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细胞毒药物与肿瘤血管生成
屠哲玮¹, 陶一飞², 董缙¹, 徐云根¹
1.中国药科大学药物化学教研室，南京 210009;2.常州市东吴医药化工技术开发有限公司，江苏常州 213026

摘要:

细胞毒药物在传统抗肿瘤化疗中运用较多，然而由于高剂量的使用难免会引起毒副作用和耐药性。为了使细胞毒药物能安全有效地治疗肿瘤，近年来，人们研究了合理运用细胞毒药物的方法，使其作用从直接杀死肿瘤细胞转变为针对肿瘤血管生成。本文就近十年来在该方面的研究作一综述。

关键词: 细胞毒药物合理应用血管生成抑制节律疗法

DOI：

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基金项目:江苏省高校“青蓝工程”资助项目(2008)；江苏省自然科学基金项目(BK2010436)

Cytotoxic Drugs and Its Anti-angiogenesis

TU Zhewei¹, TAO Yifei², DONG Jin¹, XU Yungen¹

1.Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China;2.Changzhou Dongwu Pharma-Chem Technology Development Co., Ltd., Changzhou 213026, China

Abstract:

Cytotoxic drugs are widely used in traditional antitumor chemotherapy, while the using of high dose will inevitably cause serious side effects and drug resistance. For many years, in order to make cytotoxic drugs be used safely and effectively, researchers have investigated the rational use of cytotoxic drugs, which can turn the mode of action of these drugs from killing tumor cells directly to inhibiting tumor angiogenesis. This article surveys the advances in the rational use of cytotoxic drugs.

Key words: cytotoxic drugs rational use angiogenesis inhibition metronomic chemotherapy