| 引用本文: | 张琪,陈忻,张楠,于萍.外翻肠囊法比较黄芩苷磷脂复合物与黄芩苷在大鼠小肠的吸收[J].中国现代应用药学,2011,28(6):501-504. |
| ZHANG Qi,CHEN Xin,ZHANG Nan,YU Ping.Small Intestinal Absorption Comparison of Phytosomes of Baicalin and Baicalin by Everted Intestinal Sac Method[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(6):501-504. |
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| 摘要: |
| 目的 比较黄芩苷磷脂复合物和黄芩苷在离体小肠中累积吸收的差异。方法 采用外翻肠囊法制备离体小肠吸收模型，用HPLC测定小肠吸收的黄芩苷。结果 黄芩苷及黄芩苷磷脂复合物在120 min内透过肠壁的黄芩苷含量均随时间的延长而增多；黄芩苷在小肠的吸收显著多于黄芩苷磷脂复合物(P<0.05)。结论 黄芩苷在小肠的吸收量大于黄芩苷磷脂复合物，黄芩苷磷脂复合物增加黄芩苷吸收的部位不在小肠。 |
| 关键词: 黄芩苷磷脂复合物 黄芩苷 外翻肠囊法 高效液相色谱法 |
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| Small Intestinal Absorption Comparison of Phytosomes of Baicalin and Baicalin by Everted Intestinal Sac Method |
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ZHANG Qi, CHEN Xin, ZHANG Nan, YU Ping
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College of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
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| Abstract: |
| OBJECTIVE To compare the accumulative absorption of the phytosomes of baicalin and baicalin via in vitro small intestine. METHODS Everted intestinal sacs were used and the concentration of baicalin was determined by HPLC. RESULTS Within 120 min, the concentration of the phytosomes of baicalin and baicalin were increasing over the time; the accumulative absorption of the baicalin in vitro small intestine was obviously higher than that of the phytosomes of baicalin(P<0.05). CONCLUSION The accumulative absorption of the baicalin in small intestine was higher than the absorption of the phytosomes of baicalin, the main site that phytosomes of baicalin increased the absorption of baicalin was not in small intestine. |
| Key words: phytosomes of baicalin baicalin everted intestinal sac HPLC |
