| 引用本文: | 陶雪芬,张如松.告达庭葡萄糖苷的合成及抗肿瘤活性研究[J].中国现代应用药学,2011,28(7):644-648. |
| TAO Xuefen,ZHANG Rusong.Synthesis of Caudatin Glucoside and Study on Its Antitumor Activity[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(7):644-648. |
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| 摘要: |
| 目的 合成告达庭-β-D-葡萄糖苷并研究其抗肿瘤活性。方法 以告达庭为原料在CdCO3催化下与溴活化的乙酰葡萄糖成苷，脱保护基得到目标产物，以MTT法考察其对肿瘤细胞的抑制作用。结果 合成了告达庭-β-D-葡萄糖苷，结构经1H-NMR和13C-NMR鉴定。结论 初步药理实验表明乙酰葡萄糖苷对大鼠胶质瘤细胞C6的抑制作用较强，而告达庭-β-D-葡萄糖苷对C6细胞的抑制作用与原料告达庭相当。 |
| 关键词: 告达庭 葡萄糖苷 合成 抗肿瘤活性 |
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| 基金项目:白首乌C21甾体苷类化合物抗肿瘤活性的构效关系研究(Y200805461) |
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| Synthesis of Caudatin Glucoside and Study on Its Antitumor Activity |
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TAO Xuefen, ZHANG Rusong
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Department of Medicinal Chemistry, College of Pharmaceutical Science, Zhejiang Chinese Medicinal University, Hangzhou 310053, China
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| Abstract: |
| OBJECTIVE To synthesize caudatin-β-D-glucoside and determine its antitumor activity. METHODS The target compound caudatin-β-D-glucoside was synthesized from caudatin by reaction with tetra-O-actyl-D-glucosyl bromide catalyzed by CdCO3 and then deprotection in CH3ONa/CH3OH. The antitumor activity was studied by MTT method. RESULTS Caudatin-β-D-glucoside was synthesized and characterized by 1H-NMR and 13C-NMR spetra. CONCLUSION Preliminary pharmacological result shows that the inhibitory effect of caudatin-tetra-O-actyl-D-glucoside on rat glioma cell C6 is higher than that of caudatin while caudatin-β-D-glucoside shows similar activity to caudatin. |
| Key words: caudatin glucoside synthesis antitumor activity |
