| 引用本文: | 祁浩飞,王兵,刘冰妮,刘默,刘登科.帕唑帕尼盐酸盐的合成[J].中国现代应用药学,2011,28(1):58-60. |
| QI Haofei,WANG Bing,LIU Bingni,LIU Mo,LIU Dengke.Synthesis of Pazopanib Hydrochloride[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(1):58-60. |
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| 摘要: |
| 目的 合成帕唑帕尼盐酸盐并改进合成工艺。方法 以3-甲基-6-硝基-1H-吲唑为起始原料，经N-甲基化、还原、亲核取代、成盐等反应制得帕唑帕尼盐酸盐。结果 所得产物经核磁共振氢谱、质谱、红外等确证其结构。结论 该工艺原料易得，方法简便，适合工业化生产。 |
| 关键词: 帕唑帕尼盐酸盐 抗肿瘤药 合成 |
| DOI： |
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| 基金项目:天津市自然科学基金重点项目(10JCZDJC21900) |
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| Synthesis of Pazopanib Hydrochloride |
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QI Haofei1, WANG Bing1, LIU Bingni2, LIU Mo2, LIU Dengke2
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1.Tianjin Polytechnic University, Tianjin 300160, China;2.Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
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| Abstract: |
| OBJECTIVE To synthesis pazopanib hydrochloride and optimize the process. METHODS Pazopanib hydrochloride was synthesized from 3-methyl-6-nitro-1H-indazole via N-methylation, reduction, nucleophilic substitution and salification. RESULTS Chemical structure of pazopanib hydrochloride was confirmed by 1H-NMR, MS and IR. CONCLUSION The method is suitable for industry. |
| Key words: pazopanib hydrochloride antitumor agent synthesis |
