| 引用本文: | 辛传伟,黄萍,陈雄威,王结胜,李唯佳,田云龙.消渴平合剂改善初发2型糖尿病患者胰岛β细胞功能的临床观察[J].中国现代应用药学,2011,28(1):81-84. |
| XIN Chuanwei,HUANG Ping,CHEN Xiongwei,WANG Jiesheng,LI Weijia,TIAN Yunlong.Observation on Improvement of Islet β-Cell Function in Recent-onset Type 2 Diabetes by Xiaokeping Mixture[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(1):81-84. |
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| 摘要: |
| 目的 观察消渴平合剂改善初发2型糖尿病患者胰岛β细胞功能的疗效。方法 将90例初发2型糖尿病患者随机分为3组，分别给予口服降糖药物(格列吡嗪或格列齐特缓释片，A组30例，后脱落1例)、胰岛素(B组30例，后脱落2例)及胰岛素加消渴平合剂(C组30例，后脱落2例)治疗12周，观察治疗前后临床症状、空腹血糖(FBG)、餐后2 h血糖(P2hPG)、糖化血红蛋白(HbA1c)、空腹及餐后0.5，1，2，3 h C肽、胰岛素抵抗指数及胰岛β细胞功能指数。结果 3组患者治疗后，临床症状和FBG、P2hPG、HbA1c、空腹C肽、HOMA-IS均较治疗前有统计学差异(P<0.05)，其中C组治疗后较A、B组有统计学差异(P<0.05)。A组患者C肽分泌峰值仍然较低而且后延，而B、C组患者餐后1 h C肽有明显升高，表明两组患者胰岛β细胞功能均有不同程度改善和恢复，但C组患者的效果最好。结论 对初发2 型糖尿病患者, 消渴平合剂具有一定程度的降低血糖和保护胰岛β细胞功能的作用，与胰岛素联用具有协同和增效作用。 |
| 关键词: 消渴平合剂 初发2型糖尿病 胰岛b细胞 |
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| 基金项目:浙江省中医药管理局基金项目(2009YA010) |
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| Observation on Improvement of Islet β-Cell Function in Recent-onset Type 2 Diabetes by Xiaokeping Mixture |
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XIN Chuanwei1, HUANG Ping2, CHEN Xiongwei3, WANG Jiesheng4, LI Weijia5, TIAN Yunlong5
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1.Tong De Hospital of Zhejiang Province, a. Department of Pharmacy, b. Department of Endocrinology, Hangzhou 310012, China;2.Tong De Hospital of Zhejiang Province Department of Pharmacy, Hangzhou 310012, China;3.Tong De Hospital of Zhejiang Province Department of Pharmacy,Hangzhou 310012, China;4.Tong De Hospital of Zhejiang Province Department of Endocrinology, Hangzhou 310012, China;5.Tong De Hospital of Zhejiang Province, Department of Endocrinology, Hangzhou 310012, China
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| Abstract: |
| OBJECTIVE To observe the effect of Xiaokeping mixture on improvement of islet β-cell function in recent-onset type 2 diabetes. METHODS Ninty recent-onset type 2 diabetic patients were randomly divided into 3 groups(Group A, B, C), Group A was given glipizide or gliclazide sustained-release tablets(30 patients, 1 patient dropped out), Group B was given insulin(30 patients, 2 patients dropped out), Group C was given insulin combinate Xiaokeping mixture(30 patients, 2 patients dropped out). The changes in clinical syndromes FBG, P2hPG, HbA1c, C peptide and HOMA-IR, HOMA-IS were observed before and after treatment. RESULTS After treatment, clinical symptom, FBG, P2hPG, HbA1c, fasting C peptide and HOMA-IS were improved parentally comparing with pre-treatment(P<0.05), Group C has significant difference comparing with Group A and B(P<0.05). The secretive peak value of C peptide in Group A was still low and delayed, while in Group B and C, C-peptide at 1 hour was significantly increased and indicated a certain degree of improvement and recovery of islet β-cell function. The improving effect in Group C was better. CONCIUSION To recent-onset type 2 diabetes, Xiaokeping mixture can decrease glucose and protect islet β-cell function，and shows synergistic and enhancing action when combined use with insulin. |
| Key words: Xiaokeping mixture recent-onset type 2 diabetes islet β-cell |
