表面修饰脂质纳米粒给药系统的研究进展

于莲; 崔丹; 应晓英; 杜永忠

引用本文:	于莲,崔丹,应晓英,杜永忠.表面修饰脂质纳米粒给药系统的研究进展[J].中国现代应用药学,2011,28(2):108-112.
	YU Lian,CUI Dan,YING Xiaoying,DU Yongzhong.Research Progress in Drug Delivery of Surface Modified Lipid Nanoparticles[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(2):108-112.

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表面修饰脂质纳米粒给药系统的研究进展
于莲¹, 崔丹¹, 应晓英², 杜永忠²
1.佳木斯大学药学院，黑龙江省生物药制剂重点实验室，黑龙江佳木斯 154007;2.浙江大学药学院，杭州 310058

摘要:

脂质纳米粒是一种极具潜力的新型药物传输载体，对脂质纳米粒表面修饰是近年来的研究热点。通过表面修饰的手段能有效的避免单核巨噬细胞的吞噬、延长脂质纳米粒在体内的循环时间、主动靶向于病灶部位。本文就脂质纳米粒的体内命运及脂质纳米粒表面修饰的研究进展做一综述。

关键词: 脂质纳米粒表面修饰单核吞噬细胞系统主动靶向研究进展

DOI：

分类号:

基金项目:浙江省医药卫生科学研究基金计划(2009A054)

Research Progress in Drug Delivery of Surface Modified Lipid Nanoparticles

YU Lian¹, CUI Dan¹, YING Xiaoying², DU Yongzhong²

1.College of Pharmacy, Jiamusi University, Heilongjiang Province Key Laboratory of Biological Medicine Formulation, Jiamusi 154007, China;2.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

Abstract:

Lipid nanoparticles have attracted increasing attention as potential drug carrier. The researches relating to surface modification of lipid nanoparticles become a hot spot during recent years. Through surface modification, the lipid nanoparticles could effectively decrease the phagocytosis by mononuclear phagocyte, prolong retention time in circulation, and achieve the active targeting to action site of drug. This review focused on in vivo fate of lipid nanoparticles and the developments of surface modification.

Key words: lipid nanoparticles surface modification mononuclear phagocyte active targeting research progress