| 引用本文: | 陆平,杜永忠,胡富强,袁弘,周建平.精蛋白在改进非病毒载体基因转染中的应用[J].中国现代应用药学,2011,28(4):307-311. |
| LU Ping,DU Yongzhong,HU Fuqiang,YUAN Hong,ZHOU Jianping.Potential of Protamine for Improving Non-viral Gene Transfection[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(4):307-311. |
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| 摘要: |
| 非病毒基因载体的出现，为基因治疗提供了低毒、易于大规模制备的载体。但与病毒载体相比，非病毒基因载体的转染效率仍然偏低，阻碍了非病毒基因载体的临床应用。本文旨在探讨精蛋白在改进非病毒基因载体方面的应用，希望通过合理的载体设计与优化，制备出一种高效、低毒的基因载体。 |
| 关键词: 基因载体 精蛋白 基因转染 非病毒基因载体 基因治疗 |
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| Potential of Protamine for Improving Non-viral Gene Transfection |
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LU Ping1,2, DU Yongzhong2, HU Fuqiang2, YUAN Hong2, ZHOU Jianping1
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1.Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China;2.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
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| Abstract: |
| Non-viral gene vector, even has merits of nontoxic and easy preparation, has low transfection efficiency compared with viral vector, which handicaps its clinical application. This review tends to provide a new method of improving gene transfection efficiency by protamine. With proper design and optimization, it is possible to prepare an efficient and nontoxic gene vector. |
| Key words: gene vector protamine gene transfection non-viral gene vector gene therapy |
