| 引用本文: | 张名书,夏英昊,迟浩南,刘音,胡海洋.3D打印蛇床子素螺旋环状储库型阴道环的制备[J].中国现代应用药学,2026,43(14):33-42. |
| Zhang Mingshu,Xia Yinghao,Chi Haonan,Liu yin,Hu Haiyang.The Preparation of Osthole EVA Reservoir Type Spiral Annular Vaginal Rings Using the Melt Deposition 3D Printing Technology[J].Chin J Mod Appl Pharm(中国现代应用药学),2026,43(14):33-42. |
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| 摘要: |
| 目的:通过3D打印技术制备蛇床子素/乙烯-醋酸乙烯酯(EVA)螺旋环状阴道环,考察处方因素对其体外释放的影响。方法:使用3D打印技术分别制备蛇床子素EVA螺旋环状阴道环。使用单因素法考察处方因素对药物体外释放的影响。使用红外光谱法和扫描电镜法对蛇床子素在阴道环中的状态进行表征。结果:阴道环为白色,表面平整,外观尺寸与设计一致。螺旋环状基质型阴道环比普通环状阴道环具有更高的药物突释量和累计释放量。螺旋环状储库型阴道环药物突释量显著降低。随控释层厚度增加,日均释药量降低。红外光谱和扫描电镜证明,蛇床子素结构没有发生变化,且与EVA40相容性较好。结论:螺旋环状储库型阴道环能够降低药物前期突释,增强后期药物稳定释放。 |
| 关键词: 蛇床子素 3D打印技术 醋酸乙烯酯 阴道环 体外释放 |
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| The Preparation of Osthole EVA Reservoir Type Spiral Annular Vaginal Rings Using the Melt Deposition 3D Printing Technology |
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Zhang Mingshu1, Xia Yinghao2, Chi Haonan2, Liu yin1, Hu Haiyang2
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1.LiaoNing Petrochemical University;2.Shenyang Pharmaceutical University
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| Abstract: |
| Objective: To prepare osthole ethylene vinyl acetate (EVA) spiral annular vaginal rings using 3D printing technique, to study the effect of prescription factors on the in vitro release of the vaginal ring. Methods: Osthole EVA matrix type and osthole EVA reservoir type spiral annular vaginal rings were prepared using the melt deposition 3D printing technology. The single factor examination was used to investigate the effect of prescription factors on the in vitro release of vaginal ring. The state of the osthole in the vaginal ring was characterized by infrared spectroscopy and scanning electron microscopy. Results: The 3D-printed vaginal rings were white with smooth surfaces, and the appearance and dimensions were consistent with the software design. The osthole EVA spiral ring matrix type vaginal ring had higher drug burst release and higher cumulative drug release than that of the normal ring vaginal ring. The osthole EVA spiral ring reservoir type vaginal ring showed significantly a lower drug burst release. With the thickness of the controlled-release layer increasing, the average daily drug release reduced. Infrared spectroscopy demonstrated that the structure of the osthole remained unchanged during the 3D printing process, and the scanning electron microscopy showed that the osthole was more compatible with EVA40. Conclusion: The osthole spiral ring reservoir type vaginal ring using 3D printing technique can reduce the drug burst release and stabilize the drug release in the late stage. |
| Key words: osthole 3D printing technology ethylene vinyl acetate vaginal ring drug release in vitro |
