| 引用本文: | 郭宁宁,苏力德,斯日古冷,那仁满都拉.丹参酮对细胞信号通路调控作用的研究进展[J].中国现代应用药学,2025,42(4):99-112. |
| Guo Ningning,Su Lide,Siriguleng,Narenmandula.Advances in the Regulatory Effects of Tanshinone on Signaling Pathways[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(4):99-112. |
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| 摘要: |
| 丹参酮是从我国传统中药材丹参中提取的一类脂溶性生物活性成分,其主要单体成分有丹参酮I、丹参酮ⅡA 、二氢丹参酮、3-羟基丹参酮、隐丹参酮等,这些单体具有抗菌抗炎、抗肿瘤、心血管保护等多种药理作用。多项研究表明,丹参酮可能是通过调节几种细胞信号转导通路或靶向调控疾病发生发展过程中的关键驱动分子来发挥其药理活性的,本综述主要通过对近几年丹参酮各类单体的药理作用机制研究进行全面总结,为丹参酮类药物制剂的后续研究及临床应用提供理论依据。 |
| 关键词: 丹参酮 信号通路 靶向调控 药理作用 |
| DOI： |
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| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| Advances in the Regulatory Effects of Tanshinone on Signaling Pathways |
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Guo Ningning1, Su Lide2, Siriguleng1, Narenmandula3,1
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1.Inner Mongolia Medical University;2.International Mongolian Hospital of Inner Mongolia;3.Zhejiang University
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| Abstract: |
| Tanshinone, a class of lipophilic bioactive compounds extracted from the traditional Chinese herb Salvia miltiorrhiza, primarily consists of monosubstituted compounds such as Tanshinone I, Tanshinone IIA, Dihydrotanshinone, 3-hydroxytanshinone, and Cryptotanshinone. These monosubstituted compounds exhibit diverse pharmacological effects including antibacterial and anti-inflammatory activities, anti-tumor effects, and cardiovascular protection. Multiple studies have suggested that Tanshinone may exert its pharmacological activity by modulating various cell signaling pathways or targeting key drivers of disease progression. This review aims to comprehensively summarize the pharmacological mechanisms of action of various monosubstituted compounds of Tanshinone in recent years, thereby providing theoretical support for subsequent research and clinical application of Tanshinone-based drugs. |
| Key words: tanshinone pharmacological action signaling pathway targeted regulation |
